Deformations Within Moving Kinetochores Reveal Different Sites of Active and Passive Force Generation
نویسندگان
چکیده
منابع مشابه
Deformations within moving kinetochores reveal different sites of active and passive force generation.
Kinetochores mediate chromosome segregation at mitosis. They are thought to contain both active, force-producing and passive, frictional interfaces with microtubules whose relative locations have been unclear. We inferred mechanical deformation within single kinetochores during metaphase oscillations by measuring average separations between fluorescently labeled kinetochore subunits in living c...
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ژورنال
عنوان ژورنال: Science
سال: 2012
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.1221886